HCG Pregnyl 5000iu

Manufacturer: Organon, Turkey

Pharmaceutical name: Human Chorionic Gonadotropin

Pack: 1 kit (5000 iu amp and solution)

One kit of HCG Pregnyl comprises freeze-dried powder intended for injection and a solvent for reconstitution.

 

HCG Pregnyl 5000iu is not an anabolic/androgenic steroid; rather, it is a natural protein hormone that develops in the placenta of a pregnant female. HCG is produced in the placenta right after implantation. It has luteinizing properties as it closely resembles the luteinizing hormone (LH) produced by the anterior pituitary gland. For the initial 6-8 weeks of pregnancy, the HCG produced supports the ongoing synthesis of estrogens and gestagens in the corpus luteum. Subsequently, these two hormones are generated by the placenta itself.

 

HCG is derived from the urine of pregnant women because it is excreted unchanged through the blood into the urine, filtering through the kidneys. The available HCG in the market is presented as a dry substance suitable for use by both men and women. In women, injectable HCG promotes ovulation by affecting the final stages of egg development, thus encouraging ovulation and enhancing estrogen and corpus luteum production. Its similarity to luteinizing hormone (LH), recognized for its role in the hypophysis, makes HCG particularly appealing to athletes. For men, LH stimulates Leydig cells in the testes, leading to the production of androgenic hormones (testosterone). Consequently, athletes utilize injectable HCG to boost testosterone levels.

 

HCG Pregnyl 5000iu is frequently used alongside anabolic/androgenic steroids during or post-treatment. As previously stated, both oral and injectable steroids can induce a negative feedback effect after reaching specific levels and durations of use. This feedback sends incorrect signals to the hypothalamohypophysial testicular axis, causing the hypothalamus to instruct the hypophysis to decrease or cease the secretion of FSH (follicle stimulating hormone) and LH. Therefore, testosterone production diminishes since the Leydig cells in the testes, no longer adequately stimulated due to reduced LH, cannot produce testosterone. Given the body's need for a recovery period to resume testosterone production, athletes often encounter a difficult transition phase marked by significant losses in strength and muscle mass after discontinuing steroid use.

 

Administering HCG immediately following steroid treatment helps alleviate this issue by rapidly and reliably increasing testosterone production in the testes. In cases of testicular atrophy linked to megadoses and prolonged usage, HCG aids in restoring the testes to their original size. Many athletes opt for HCG during their steroid cycles for two to three weeks to prevent testicular atrophy, often witnessing substantial gains in strength and muscle mass during this period. This phenomenon occurs because HCG raises the athlete's testosterone levels while steroids cause a high concentration of anabolic substances in the bloodstream. Numerous bodybuilders, powerlifters, and weightlifters report diminished libido towards the end of an intense training cycle, particularly before or after competitions and especially towards the conclusion of steroid treatment.

 

Athletes accustomed to using steroids typically accept this as a temporary condition. However, individuals who consistently use steroids throughout the year and may deal with psychological effects or risks to personal relationships should consider this drawback if taking HCG at regular intervals. Treatment with HCG can generally improve reduced libido and spermatogenesis caused by steroids.

 

Most athletes, however, turn to HCG Pregnyl 5000iu at the conclusion of a treatment regimen to prevent a "crash" and to facilitate the transition back to "natural training." A critical factor for this to be effective is a gradual reduction in steroid intake or dosage before HCG is initiated. While HCG effectively boosts endogenous plasma testosterone levels quickly and significantly, it is not a perfect solution to avert strength and mass loss after steroid treatment.

 

The athlete is likely to undergo a delayed adjustment phase, as has been commonly observed. Although HCG stimulates endogenous testosterone production, it does not assist in restoring the normal hypothalamic/pituitary testicular axis. Following prolonged steroid use, the hypothalamus and pituitary gland remain unresponsive, even during HCG administration, as the endogenous testosterone resulting from exogenous HCG suppresses endogenous LH production. Once HCG is stopped, the athlete still faces a re-adjustment period that is merely postponed by HCG use. Consequently, seasoned athletes frequently combine Clomid and Clenbuterol after using HCG or may begin another steroid cycle immediately. Some use HCG just to take a break from steroids for two to three weeks.

 

Regrettably, many bodybuilders still believe that HCG assists in achieving hardness during competition preparation by breaking down subcutaneous fat, thereby enhancing definition and vascularity. However, HCG package inserts clearly indicate that it does not affect fat mobilization, appetite, hunger sensation, or fat distribution. HCG has not been proven effective as adjunctive therapy for obesity, nor does it enhance fat loss beyond that achieved through caloric restriction.

 

Athletes should administer 5000 IU every 5 days. Given that testosterone levels remain significantly elevated for several days post-injection, more frequent HCG injections within this timeframe are unnecessary. The appropriate dosage is at the athlete's discretion and should be based on the duration of prior steroid usage and the potency of the specific steroids utilized. Athletes using steroids for over three months or primarily employing highly androgenic steroids such as Androlic, Sustanon 250, Cypionate, and Dianabol (D-bol) should consider higher dosages. The effective range is usually 2000-5000 IU per injection, every 5 days, with HCG being administered for a maximum of 4 weeks.

 

If male athletes use HCG for extended weeks at high dosages, there is a risk that the testes may poorly respond to subsequent HCG use and release of the body's own LH, potentially resulting in permanent inadequate gonadal function. Cycles with HCG should generally last around 3 weeks, with a recovery period of at least a month in between. For instance, HCG could be taken for 2 or 3 weeks during a cycle and for an additional 2 or 3 weeks at the cycle's end. It has been speculated that prolonged HCG usage could permanently suppress the body's natural gonadotropin production, which is why short cycles are advised.

 

HCG Pregnyl 5000iu can produce side effects similar to those of injectable testosterone. Increased testosterone levels often lead to elevated estrogen levels, which can cause gynecomastia. This may present as temporary breast enlargement or exacerbate pre-existing breast tissue in men. To mitigate this risk, savvy athletes often take HCG alongside an antiestrogen. Male athletes may also experience more frequent erections and heightened sexual desire. At high doses, HCG can cause acne vulgaris and fluid retention. The latter is particularly notable, as water retention triggered by HCG can result in a swollen and puffy appearance in the muscle tissues. Athletes who have previously elevated their testosterone levels using Clomid and then choose to administer HCG may experience significant water retention and pronounced feminization symptoms (such as gynecomastia and tendency to accumulate fat around the hips). This occurs because high testosterone levels convert readily to estrogens. In younger athletes, HCG can lead to premature growth plate closure and stunted growth, similar to anabolic steroids. Other potential effects of HCG intake include mood fluctuations and elevated blood pressure. HCG Pregnyl 5000iu may also be utilized as "bridge" doping before competitions with doping controls.

 

The method of administering HCG is somewhat unconventional. This choriongonadotropin substance appears as a white, powdery freeze-dried product often used as a compress. Due to its low structural stability, it may easily disintegrate, leading to an impression of reduced volume. However, this is inconsequential, as neither efficacy nor substance loss occurs. Each HCG package includes an additional ampule with an isotonic sodium chloride injection solution. After both ampules are opened in a sterile environment, the solution is injected into the HCG ampule and mixed with the powder. The resulting solution is then ready for intramuscular injection. If only a portion of the solution is utilized, any remaining should be refrigerated. There is no need to refrigerate the unmixed HCG, but it should be kept out of light and below 25°C. HCG is relatively costly.